Mfoniso Udofia's plays, Sojournersrunboyrun, Her Portmanteau, and In Old Age have been seen at the American Conservatory Theater [A.C.T.], New York Theatre Workshop [NYTW], The Playwrights Realm, Magic Theater, National Black Theatre, Strand Theater Company, and Boston Court. She’s the recipient of the 2017 Helen Merrill Playwright Award, the 2017-18 McKnight National Residency and Commission at The Playwrights’ Center and is a member of the New Dramatists class of 2023. Mfoniso is currently commissioned by A.C.T., Hartford Stage, Denver Center, A.C.T., Roundhouse, and South Coast Repertory. Her plays have been developed by Manhattan Theatre Club, A.C.T., NYTW, The Playwrights Realm, McCarter Theatre, OSF, New Dramatists, PCS’s JAW Festival, Berkeley Rep’s Ground Floor, The OCC, Hedgebrook, Sundance Theatre Lab, Space on Ryder Farm, Page 73, New Black Fest, Rising Circle and more.

She has worked as a television writer on the third season of Netflix’s 13 Reasons Why and the first seasons of both Apple TV's  Little America and Pachinko.

As an actress, she recently appeared off-Broadway in Ngozi Anyanwu's, The Homecoming Queen. She's also appeared in the feature film, Fred Won't Move Out.